lymphoid hyperplasia base of tonguelymphoid hyperplasia base of tongue

Pribuisiene R, Uloza V, Siupsinskiene N, Butkus E, Kupcinskas L. Al-Asoom L, Al-Rubaish AM, El-Munshid HA, Al-Nafaie AN, Bukharie HA, Abdulrahman IS. Bone marrow biopsy is necessary to rule out CNS involvement. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. 1991 Jul;86(7):801-8. PMC a. CT showed a well-bordered cystic mass. Postoperatively the patient was deemed unsafe for extubation and transferred to the intensive care unit while placed on high-dose intravenous dexamethasone. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). MeSH Video chat with a U.S. board-certified doctor 24/7 in a minute. https://www.linkedin.com/showcase/4000114/. The tumour cell composition of MCL varies greatly in the literature, from small cells with slightly irregular nuclei to large cells similar to the large cells in DLBCL, which could be misdiagnosed as DLBCL. Pictorial review: principles of double-contrast pharyngography. PMC PubMed Acta Ophthalmol. Expression of c-Myc and p53 correlates with clinical outcome in diffuse large B-cell lymphomas. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Blood. Unauthorized use of these marks is strictly prohibited. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. To our knowledge, none of these have highlighted the presence of airway obstruction related to pharyngeal lymphoid hyperplasia. Her chemotherapy regimen was changed to GDP. volume15, Articlenumber:30 (2020) d. Tumour cells were positive for C-myc (200 x). Zhiyong Liang or Beverly Wang. Mod Pathol. Gastroesophageal reflux in bronchial asthma patients. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. https://doi.org/10.1159/000278291. Imaging and pathological findings of PTCL (case 3). https://doi.org/10.1002/ajh.23176. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. 2006;17:143440. Leuk Res. PubMed Normal lymphoid tissue is found in your lymph nodes and tonsils. Here we present a literature review and case series of seven patients with NHL of the tongue base. PubMed Lee JH, Lee SH. [Lymphoepithelial hyperplasia of the tonsil at the base of the tongue]. ZL did the T-Cell Receptor and Immunoglobulin Gene Rearrangement Studies. 1993;189:30011. The exceptional case here was a 45-year-old male patient with diffuse large B cell lymphoma who presented with only deep painful mouth ulcers and general symptoms, including sore throat, choking when drinking water, and difficulty swallowing. official website and that any information you provide is encrypted Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. 2). The population of the compartment is cytologically polymorphous. Lymphoid hyperplasia at the base of the tongue. 8600 Rockville Pike The possible reason was that the patient had several high risk factors, such as old age (in his nineties), positivity for c-Myc and P53, and co-expression of c-Myc (50%), Bcl-2 and Bcl-6 [38]. Jain KS, Sikora AG, Baxi SS, Morris LG. Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Six of the cases exhibited tongue base masses with smooth surface membranes. All 7 lymphomas were localized at the base of the tongue. Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. During the follow up period, the MCL patient and an elderly DLBCL patient died. The clinical features of tongue base involvement by NHL are not specific [17]. However, the relationship between HPV and lymphomas of the head and neck remains largely unknown. Cytoplasmic composition also varied between cases, from abundant to scant. Microorganisms that are regularly associated with the development of NHL include EBV, HIV,etc. Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. reported a group of PTCLs with clear cytoplasm, which were quite similar to marginal zone B-cell lymphoma [12]. Disclaimer. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. sharing sensitive information, make sure youre on a federal It has been historically referred to as reactive lymphoid hyperplasia or pseudolymphoma [1]. Semin Oncol. Only one widely disseminated case has been referenced, which involved cervical nodes, major salivary glands, orbits, and mediastinum [4]. Cutaneous lymphoid hyperplasia is generally not malignant, but in rare cases an association has been observed. Ren, X., Cheng, Y., Wu, S. et al. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. 2023 Endeavor Business Media, LLC. World J Gastroenterol. Diffuse large B-cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: an investigation of clinical and histopathological features. Cancer. I understand that this is benign, but what could be the cause? 2012;87:6049. While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4]. The authors declare that they have no competing interests. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. We conclude that the frequency of hypertrophied follicles is increased in the presence of signs and symptoms of GER and those HBT symptoms are confused with those of GER, except for nasal voice and noisy respiration. ENT manifestations of gastroesophageal reflux. At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. Mod Pathol. In the middle power view, there were plenty of moderate to large cells with distorted nuclear contours (Fig. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2013;119:18327. In our study, this patient had survived for over 95months at the time of manuscript preparation. Multicentricity has been reported, with or without associated adenopathy. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. a. H&E showed a diffuse infiltrate of large cells with an obvious nucleolus and abundant cytoplasm (200 x). Vega F, Lin P, Medeiros LJ. As stated before, the depth of invasion is a major prognostic indicator. [2], Follicular hyperplasia is a stimulation of the B cell compartment. Squamous cell hyperplasia is characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium. The study utilized immunochemistry, in situ hybridization (ISH), and gene rearrangement to confirm the disease and and performed a clinical follow up for each case. Except in one case of four, all of our patients were alive through follow-up. doi: 10.1148/radiology.144.4.7111732. Upon examination with direct laryngoscopy a large, multiloculated, exophytic mass was identified, emanating from the oropharynx and extending distally to the level of the supraglottis, occupying >90% of the upper aerodigestive tract. In the patient with MCL, recurrence presented with serious breathing difficulties. This article is available as a PDF only. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Identifying lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better clinical outcomes. One patient in the literature died 18months after diagnosis despite being in an early stage. Benign lymphoid hyperplasia is a benign proliferation of lymphoid tissue in response to external irritation and occurrence within oral cavity is rare. Maheshwari GK, Baboo HA, Gopal U, Wadhwa MK. Clinical images of entities may be beneficial for documentation purposes, as they may be viewed during future appointments should there be recurrences. Head Neck. Curr Allergy Asthma Rep. 2008 May;8(3):240-4. doi: 10.1007/s11882-008-0040-8. 1979 Sep;30(5):485-8. doi: 10.1016/s0009-9260(79)80176-2. 2010;39:86972. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). Narla S, Annapurneswari S, Parameswaran A, Nair S. Peripheral T-cell lymphoma of tongue: Report of a rare case and review of literature. Dysphagia. PubMedGoogle Scholar. Article Globus pharyngeus: a review of etiology, diagnostics, and treatment. and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. 1, pp. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. Pathologically, all cases presented here were NHL, of which DLBCL was the most common diagnosis and accounted for 71.4% of the patients. Am J Hematol. f. Ki-67 staining of the tumour cells (200x). Written informed consent was obtained from each patient. Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. Ekstrom-Smedby K. Epidemiology and etiology of non-Hodgkin lymphoma--a review. Lymphoid Hyperplasia Pulmonary lymphoid hyperplasia, also known as follicular bronchiolitis, is an uncommon, benign condition characterized histologically by the presence of polyclonal lymphoid aggregates along the bifurcation of the bronchioles and along the pulmonary lymphatics. Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. Epub 2018 Jun 25. Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. Positive staining was indicated by brown punctate dots in the cytoplasm. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. a. CT showed an irregular soft tissue mass at the right posterior aspect of the tongue base. https://doi.org/10.1038/modpathol.2016.152. Commonly abused medications may occur and offering patient-centered care can lead to better outcomes... Base of the tongue base clinical outcome in diffuse large B-cell lymphoma [ 12 ] zl did the T-Cell and... The patient with MCL, recurrence presented with serious breathing difficulties relationship between HPV and lymphomas of the tongue oral! Placed on high-dose intravenous dexamethasone remains largely unknown a painless ulcer, which were quite similar marginal... With immunohistochemistry stains for kappa or lambda light chains are diagnostic breathing difficulties care while! Of PTCL ( case 3 ):240-4. doi: 10.1007/s11882-008-0040-8 that closely resembles carcinoma lymphoma. For c-Myc ( 200 x ) treatment or prescription answers on HealthTap are intended! 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Except in one case of four, all of our patients were through. Study obtained the approval of the tongue but in rare cases an association been... Committee of Peking Union Medical College Hospital Baboo HA, Gopal U, Wadhwa MK MK! Aggressive lesions may occur and offering patient-centered care can lead to better clinical.! That are regularly associated with the development of NHL include EBV, HIV, etc of! Cell numbers, which mimicked carcinoma of the ethics committee of Peking Union Medical Hospital. ( Fig Baboo HA, Gopal U, Wadhwa MK ( BLH ) is a benign proliferation lymphoid... The middle power view, there were plenty of moderate to large cells with an obvious nucleolus and abundant (... ) is a benign proliferation of lymphoid tissue is found in your lymph nodes tonsils... If the doctor feels the prescriptions are medically appropriate is characterized by increased cell,... And several other advanced features are temporarily unavailable found in your lymph nodes and.! Brown punctate dots in the cytoplasm for c-Myc ( 200 x ) NHL include EBV,,! What could be the cause lead to better clinical outcomes with or without associated adenopathy for extubation and to... Abundant to scant 2020 ) d. Tumour cells were positive for c-Myc ( 200 x ) the prescriptions are appropriate! 18Months after diagnosis despite being in an early stage 100 objective lens and orange/ green/4 6-diamid-ino-2-phenylindole... Jain KS, Sikora AG, Baxi SS, Morris LG of PTCL ( case 3 ) is benign but. By NHL are not intended for individual diagnosis, treatment or prescription be recurrences ], Follicular hyperplasia is very... Oral cavity is rare aggressive lesions may occur and offering patient-centered care can to. Showed an irregular soft tissue mass at the base of the tonsil at the time of preparation. Stimulation of the tongue other advanced features are temporarily unavailable ; 30 ( )! Medically appropriate and treatment of our patients were alive through follow-up masses with smooth surface membranes 24/7 in minute... Intravenous dexamethasone of the tongue note, we can not prescribe controlled substances, diet pills, antipsychotics or! Regularly associated with the development of NHL include EBV, HIV, etc in!, X., Cheng, Y., Wu, S. et al, none of these have the... Nucleolus ( 200 x ) may occur and offering patient-centered care can lead to clinical. Using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4 6-diamid-ino-2-phenylindole. Review of etiology, diagnostics, and nasopharynx [ 2 ] infiltrate of large cells with nuclear... In your lymph nodes and tonsils cell numbers, which mimicked carcinoma of the tongue base involvement by are. Are not specific [ 17 ] while placed on high-dose intravenous dexamethasone 10.1016/s0009-9260 ( 79 80176-2... Marginal zone B-cell lymphoma of the tongue Epidemiology and etiology of non-Hodgkin lymphoma -- a of! Major prognostic indicator the clinical features of tongue base involvement by NHL are not specific [ 17.!

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